High intracellular level of citrate â—» glycolysis and â—» gluconeogenesis. High intracellular level of citrate [Select] glycolysis and [Select] gluconeogenesis.
Added by Timothy V.
Close
Step 1
Citrate is an intermediate in the citric acid cycle (Krebs cycle). High levels indicate sufficient energy stores, thus reducing the need for glycolysis (glucose breakdown for energy) and promoting gluconeogenesis (glucose synthesis from non-carbohydrate Show more…
Show all steps
Your feedback will help us improve your experience
Aditya Sood and 61 other Biology educators are ready to help you.
Ask a new question
Labs
Want to see this concept in action?
Explore this concept interactively to see how it behaves as you change inputs.
Key Concepts
Recommended Videos
How does citrate from the citric acid cycle affect glycolysis?
C) PFK is inhibited when ATP and citrate (an intermediate in the TCA cycle) are abundant inside the cell. Explain the metabolic connection between high [ATP] and high [citrate] (i.e. how does one affect the other?). Then explain the metabolic logic of using these molecules to inhibit PFK (6 pts, 4-6 sentences). C) The TCA cycle product is ATP, and citrate is consumed and regenerated by the continuing reactions in the TCA cycle. High [citrate] will generate high [ATP], but this eventually reduces the rate of the TCA cycle. Citrate synthase in the TCA cycle is inhibited by high [ATP] because high [ATP] means the cell has enough energy and does not need to run the cycle. [ATP] and [citrate] go together, so both of them can allosterically regulate PFK.
Shaiju T.
How does citrate from the citric acid cycle affect glycolysis? a. Citrate and ATP are negative regulators of phosphofructokinase-1. b. Citrate and ATP are negative regulators of hexokinase. c. Citrate and ATP are positive regulators of phosphofructokinase-1. d. Citrate and ATP are positive regulators of hexokinase.
Recommended Textbooks
Biology for AP Courses
Objective Biology for NEET
Introduction to General, Organic and Biochemistry
Transcript
18,000,000+
Students on Numerade
Trusted by students at 8,000+ universities
Watch the video solution with this free unlock.
EMAIL
PASSWORD