Question

Histidine has the following pKa values: pK1 = 1.82, pK2 = 9.17, pKR = 6.0. a) Draw all the different ionic forms of Histidine going from low pH to high pH and circle the dominant form of Histidine at its isoelectric point. b) Calculate the pI for this amino acid. c) Sketch an accurate titration curve for a titration of Histidine with NaOH. Label the equivalence points, the half-equivalence points, and the pI. d) Indicate which species of Histidine is present at different points in your titration curve. e) Indicate the buffer regions of Histidine in your graph.

          Histidine has the following pKa values: pK1 = 1.82, pK2 = 9.17, pKR = 6.0.

a) Draw all the different ionic forms of Histidine going from low pH to high pH and circle the dominant form of Histidine at its isoelectric point.

b) Calculate the pI for this amino acid.

c) Sketch an accurate titration curve for a titration of Histidine with NaOH. Label the equivalence points, the half-equivalence points, and the pI.

d) Indicate which species of Histidine is present at different points in your titration curve.

e) Indicate the buffer regions of Histidine in your graph.

Added by Samantha M.

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