How does the activated alpha subunit of G-protein activate its downstream target adenylyl cyclase? The alpha subunit phosphorylates adenylyl cyclase. The alpha subunit binds to a channel in the ER membrane to increase Ca++ in the cytosol. The alpha subunit converts ATP to cAMP. The alpha subunit binds directly to adenylyl cyclase, which remains active until the alpha subunit disassociates.
Added by Monica S.
Close
Step 1
Step 1: The alpha subunit of a G protein is activated upon binding to GTP. Show more…
Show all steps
Your feedback will help us improve your experience
Marlyn Joyce and 84 other Biology educators are ready to help you.
Ask a new question
Labs
Want to see this concept in action?
Explore this concept interactively to see how it behaves as you change inputs.
Key Concepts
Recommended Videos
When a ligand binds to a G-protein coupled receptor (GPCR): GTP leaves the G protein and GDP binds to it The beta subunit of the G protein dissociates from the alpha and gamma subunits The alpha subunit bound to GTP activates other molecules in the cell The alpha subunit activates kinases
Bryan V.
The alpha subunit of the heterotrimeric G protein is inactive when receptors bind to adrenaline, active when bound by GTP, active when bound by GDP, and remains complexed with beta/gamma subunits. Which statement about GPCRs is false? GPCRs span the membrane 7 times. GPCRs physically interact with adenylyl cyclase. GPCRs activate PKC signaling. Activation of GPCRs can lead to cytoplasmic Ca2+.
Sukhada S.
If membrane proteins are integrated into the ER membrane by means of the ER protein translocator (which is itself composed of membrane proteins), how do the first protein translocation channels become incorporated into the ER membrane?
Recommended Textbooks
Biology for AP Courses
Objective Biology for NEET
Introduction to General, Organic and Biochemistry
Transcript
Watch the video solution with this free unlock.
EMAIL
PASSWORD