How does the binding of a signal molecule activate an RTK for downstream signaling?
Added by Amy J.
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Step 1: When a signal molecule binds to the extracellular domain of the receptor tyrosine kinase (RTK), it induces a conformational change in the receptor. Show more…
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How does the binding of a signal molecule activate an RTK for downstream signaling? ----> The RTK forms a dimer and cross-phosphorylates itself. ----> The RTK is an ion channel that opens in response to ligand binding. ----> The RTK changes conformation to stimulate a G-protein. ---> The RTK undergoes a cleavage event to release the cytosolic portion. Question-2: Which of the following is NOT an intracellular signaling protein activated by an RTK? a. PI-3-kinase b. Trimeric G-proteins c. Ras d. monomeric GTPase Question-3: The active form of a monomeric GTP-binding protein is the.... a. GTPase-activating protein (GAP). b. GTP-bound form. c. guanine nucleotide exchange factor (GEF). d. GDP-bound form
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