How does the eukaryotic translation initiation complex locate the correct start codon? A. The General Transcription Factors locate the promoter, then help RNA polymerase enter the complex to form the preinitiation complex. B. The initiation complex moves the small ribosomal subunit through the 5' UTR, scanning for the Kozak sequence 5' ACCAUG-3'. C. The true start codon is the first ATG encountered downstream of the Shine-Dalgarno sequence. D. The pre-initiation complex moves the ribosome through the 3' UTR, scanning for the Kozak sequence.
Added by Lisa C.
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So, this option is not correct. Option B mentions the Kozak sequence, which is important for translation initiation in eukaryotes. This option seems plausible. Option C refers to the Shine-Dalgarno sequence, which is involved in translation initiation in Show more…
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How does the eukaryotic initiation complex locate the correct start codon? The correct start codon is embedded in the Kozak sequence. It is the first ATG encountered downstream of the Shine-Dalgarno sequence. The correct start codon is the formyl-ATG, which will encode for fMet in the protein. The initiation complex moves the small ribosomal subunit along the 3' UTR.
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