if cell is heterozygous for loss of function mutation that cause the protein TP53 encodes for to bind tightly and constitutively to the DNA of its target genes then how would this mutation affect the cell cycle
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The protein TP53 is a tumor suppressor protein that plays a crucial role in regulating the cell cycle and preventing the formation of cancerous cells. Show more…
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Suppose that a cell is heterozygous for a mutation that caused $p 53$ to bind tightly and constitutively to the DNA of its target genes. How would this mutation affect the cell cycle? Would such a cell be expected to be more or less sensitive to the effects of ionizing radiation?
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