If fantasin is required for a muscle cell to contract. What would happen to muscle contraction if we delete DNA sequences A, B and C?
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Consider this scenario: A cell biologist is studying the movement of sarcomeres to understand how muscle contraction is regulated. This scientist is able to culture individual muscle fibers in the laboratory for short periods of time (up to 12 hours); during this culture time, the muscle fibers remain alive and are able to respond to stimuli as they would if they were still part of a functioning muscle. Review the critical steps that are involved in muscle contraction (release of acetylcholine at the neuromuscular junction, release of calcium in the muscle fiber, active site exposure, cross bridge formation, myosin head movement, cross bridge detachment, myosin reactivation). Tell me how movement of the thin and thick filaments would be impacted I each scenario. 1. An action potential is generated in the cultured muscle fiber. At the same time, the muscle fiber is treated with a drug that prevents ATP from binding to myosin. How and why would movement of the thin and thick filaments be impacted in this scenario?
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Predict the consequences of having the following condition develop in a muscle in response to a stimulus: (a) Na+ ions cannot enter the skeletal muscle fiber; (b) inadequate ATP is present in the muscle fiber before a stimulus is applied; and (c) adequate ATP is present within the muscle fiber but action potentials occur at a frequency so great that calcium is not transported back in to the sarcoplasmic reticulum between individual action potentials.
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Muscle Contraction Consider what would happen to a muscle cell with the mutations described below. Would the muscle cell fail to contract (paralysis), or irreversibly contract (tetanus)? Be sure to explain your answers. a) A mutation that blocks the release of acetylcholine (ACh) from motor neurons would lead to... paralysis or tetanus (irreversible contraction) Explain: b) A mutation that prevents calcium from being released from the sarcoplasmic reticulum (SR) would lead to... paralysis or tetanus (irreversible contraction) Explain c) A mutation that prevents calcium from being pumped back into the SR would lead to... paralysis or tetanus (irreversible contraction) Explain d) A mutation that prevents tropomyosin from binding to calcium would lead to... paralysis or tetanus (irreversible contraction) Explain e) A mutation that prevents tropomyosin from releasing calcium would lead to... paralysis or tetanus (irreversible contraction) Explain
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