If you were to clone the telomerase gene and overexpress it in the somatic cells of a mouse, what effect would it have? Question 4 options: 1) The mouse would age prematurely. 2) The mouse would not age 3) The mouse would develop cancers. 4) The gametes of the mouse become immortal 5) The rate of DNA replication in somatic cells would slow down.
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Telomerase is an enzyme that adds repetitive nucleotide sequences to the ends of chromosomes (telomeres), which helps maintain their length and stability during cell division. In most somatic cells, telomerase is not active, leading to gradual telomere shortening Show more…
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Suppose you have a drug that specifically inhibits telomerase. You administer the drug to mice. Which of the following outcomes might reasonably be expected? More than one answer may be correct, so you may select multiple answers. You will gain partial credit for each correct answer selected and you will lose partial credit for each incorrect answer selected. Treated mice are healthy and reproduce well but continuing drug treatment into the third generation and beyond results in sterility. The mice die within 24 hours. The treated mice appear healthy throughout a normal lifespan but they are sterile. The mice appear healthy for a period of several weeks, but then develop cancer and die.
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You have generated a mouse strain in which the mice cannot make functional telomerase. You predict that these mutant mice will: Group of answer choices A. have broken, fragmented chromosomes B. will exhibit increased lifespan C. have stem cells that undergo progressive chromosome shortening after each cell division D. none of the above
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