Imagine your lab studies mechanisms of tooth development using the laboratory mouse as a model system and you have made a CRISPR/Cas mutant for a gene expressed by ameloblasts, which is required for their secretion of enamal in a tissue culture model of tooth development. Unexpectedly and unfortunately, the embryos die long before teeth develop. This would likely be an example of:gene conversion.epistasis dominance crossing-overpleiotropy
Added by Sarah D.
Step 1
The lab is studying tooth development using a CRISPR/Cas mutant for a gene expressed by ameloblasts, which are cells responsible for enamel secretion. Show more…
Show all steps
Your feedback will help us improve your experience
Josee Pacheco and 53 other Biology educators are ready to help you.
Ask a new question
Labs
Want to see this concept in action?
Explore this concept interactively to see how it behaves as you change inputs.
Key Concepts
Recommended Videos
Identified is a loss of function recessive mutation in mice affecting tooth development.
Josee P.
A genetic screen is performed, aimed at identifying all the genes affecting tooth development. One of the mutations has the phenotype where the canine tooth looks like a molar. This phenotype is less severe in heterozygous animals than in homozygous animals. Also noticed is the heterozygous animals have a more severe phenotype than animals where the mutation is uncovered by a deletion (meaning: heterozygous for the mutation and a deletion in the same region as your mutation. These and additional genotypic and phenotypic information is provided below in the form of genetic symbols.
You performed a genetic screen aimed at identifying all the genes affecting tooth development. One of the mutations results in the tooth canine tooth looking like a molar tooth. This phenotype less severe in heterozygous animals than in homozygous animals. You also notice that the heterozygous animals have a more severe phenotype than animals that are heterozygous but also carry have a duplication including an additional copy of the wild type gene (i.e. m/+ + --> one mutant copy of the gene and two wild type copies of the gene). Hint = m/m > m/+ > m/+ + What kind of mutation have you identified? Justify your answer.
Sri K.
Recommended Textbooks
Biology for AP Courses
Objective Biology for NEET
Introduction to General, Organic and Biochemistry
Transcript
Watch the video solution with this free unlock.
EMAIL
PASSWORD