In Crohn’s disease, which areas of the gastrointestinal tract can be affected by the disease?
Added by Lori B.
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Step 1: Understand that Crohn’s disease is a type of inflammatory bowel disease (IBD) characterized by chronic inflammation. Show more…
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What is the relationship between Crohn's disease and inflammatory bowel disease? Multiple Choice Crohn's disease is one of the most common inflammatory bowel diseases. Inflammatory bowel disease is a type of Crohn's disease. They are two separate diseases, but both affect only the colon. Crohn's disease affects the colon, but inflammatory bowel disease affects the small intestine. In Crohn's disease, small pouches form in the muscularis, while in inflammatory bowel disease, inflammation occurs throughout the digestive tract.
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Crohn's Disease (CD) is a type of inflammatory bowel disease characterized by abdominal pain, diarrhea, vomiting, and weight loss among other things. Dysfunctional "barriers" between intestinal epithelial cells were thought to contribute to these problems. Hence, researchers were interested in understanding molecular differences in epithelial cells that line the GI tract in healthy and CD patients. To this end, they isolated proteins from the GI epithelial cells and performed a Western blot (shown below), using antibodies against a variety of tight junction proteins. 1. Please list any tight junction proteins that were expressed DIFFERENTLY in control vs. Crohn's Disease (CD) samples. 2. Comment on whether they were upregulated or downregulated in the disease state. 3. Hypothesize on HOW upregulation and downregulation of tight junction proteins could affect intestinal epithelial cell function.
Farhan A.
Potential disruption: considering the patients symptoms , patient experiences frequent stomach pain nausea and changes in bowel habits, how might this epithelia tissue be damaged or malfunctioning
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