In most mammalian cells, fructose is metabolized into fructose-6-phosphate, an intermediate of glycolysis. From this point, glycolysis proceeds as usual. However, in liver cells, the catabolism of fructose follows a different pathway.
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Fructose is a ketohexose monosaccharide found in honey, fruits, and other sources. It is also added to some foods and drinks as a sweetener. Much of the fructose taken in through digestion is taken up and processed by the liver, where it is phosphorylated and cleaved. glucose fructose Which statements accurately describe how fructose metabolism in the liver differs from glucose metabolism? The presence of fructose inhibits the entrance of glucose into glycolysis. Two products of the fructose 1-phosphate pathway can enter glycolysis. The fructose 1-phosphate pathway can deplete intracellular phosphate/ATP. Fructose enters a separate metabolic pathway from glucose, which enters the glycolytic pathway.
Suman K.
Fructose enters the glycolytic pathway at two different points, depending on the cell type (liver versus non-liver cells). Describe where fructose enters the pathway in non-liver cells, including the enzyme(s) responsible. Do the same for fructose entering the pathway in liver cells. Why can't liver cells use the same mechanism as non-liver cells? (6 pts)
In the liver, fructose can be converted into glyceraldehyde 3 -phosphate and dihydroxyacetone phosphate without passing through the phosphofructokinase-regulated reaction. Show the reactions that make this conversion possible. Why might ingesting high levels of fructose have deleterious physiological effects?
Sri K.
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