In one variant of human hemoglobin, K at position 82 of the beta subunit is replaced by N. In the normal structure of hemoglobin, this K at position 82 projects into the central BPG binding cavity of the hemoglobin tetramer. Predict the effect that this mutation might have on the normal function of hemoglobin and provide as much detail as you can to justify your answer.
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In the normal structure of hemoglobin, there is a lysine (K) residue at position 82 in the beta subunit. Show more…
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