00:01
Hi student, this question is based on macrometrics and macrometrics is defined as it is science and technology of small particles particularly in field of pharmaceuticals.
00:16
It deals with study of various physical and chemical properties of the particle such as size, shape etc.
00:24
These properties play important role in formulation, processing and performance of the pharmaceutical dosages.
00:34
Now we see the method of determination of particle size of powder that is first method is sieve analysis, second method is the microscopy, third method is sedimentation, fourth method is laser diffraction, fifth method is dynamic light scattering and sixth one is the called turr -turr method and now we discuss choose of sieves with different mesh and that is first one is select appropriate sieves, choose series of sieve with different mesh size that cover the expected particle size range or range of powder and the second one is stack the sieves, third one is weight sample, then fourth one is place sample on top top sieves, fifth one is the sieve sample and the sixth one is weight well with the sample that is here fraction after sieving and seventh one is and seventh one is calculate particle size distribution.
05:25
Now we discuss macrometrics contributors to the pharmaceutical dosage form in several ways.
05:32
First one is solubility, solubility and dissolution rate that is smaller particle have larger surface area which can increase solubility and dissolution rate of the poorly soluble drugs leading to improve the bioavailability...