Question

In rodents, certain stimuli can induce a signaling pathway that ultimately causes the release of the nonpolar steroid hormone corticosterone from the adrenal gland into the blood. Corticosterone can bind to intracellular receptors in kidney cells. After binding corticosterone, corticosterone receptors function as transcription factors by binding DNA and activating gene expression. a) T/F Corticosterone has a specific three-dimensional shape that is essential for proper binding to its receptor. b) T/F Corticosterone can have indirect effects on cells that do not have corticosterone receptors. c) T/F Corticosterone receptors can bind to any DNA sequence in order to activate transcription. d) T/F Corticosterone can enter target cells through simple diffusion across the plasma membrane. e) T/F Under normal conditions, corticosterone levels in the blood will eventually return to their original levels once the initial stimulus is removed.

          In rodents, certain stimuli can induce a signaling pathway
that ultimately causes the release of the nonpolar steroid hormone
corticosterone from the adrenal gland into the blood.
Corticosterone can bind to intracellular receptors in kidney cells.
After binding corticosterone, corticosterone receptors function as
transcription factors by binding DNA and activating gene
expression.
a) T/F Corticosterone has a specific three-dimensional shape
that is essential for proper binding to its receptor.
b) T/F Corticosterone can have indirect effects on cells that do
not have corticosterone receptors.
c) T/F Corticosterone receptors can bind to any DNA sequence in
order to activate transcription.
d) T/F Corticosterone can enter target cells through simple
diffusion across the plasma membrane.
e) T/F Under normal conditions, corticosterone levels in the
blood will eventually return to their original levels once the
initial stimulus is removed.

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Added by Anthony W.

Biology for AP Courses

Julianne Zedalis, John Eggebrecht

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Solved by Expert Sukhwinder N

04/17/2022

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In rodents, certain stimuli can induce a signaling pathway that ultimately causes the release of the nonpolar steroid hormone corticosterone from the adrenal gland into the blood. Corticosterone can bind to intracellular receptors in kidney cells. After binding corticosterone, corticosterone receptors function as transcription factors by binding DNA and activating gene expression. a) T/F Corticosterone has a specific three-dimensional shape that is essential for proper binding to its receptor. b) T/F Corticosterone can have indirect effects on cells that do not have corticosterone receptors. c) T/F Corticosterone receptors can bind to any DNA sequence in order to activate transcription. d) T/F Corticosterone can enter target cells through simple diffusion across the plasma membrane. e) T/F Under normal conditions, corticosterone levels in the blood will eventually return to their original levels once the initial stimulus is removed.

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Transcript

00:01 Here we have been told that in rodents there are certain kind of stimuli which induce a signaling pathway and this causes the release of non -poral steroid hormone, that is corticosterone, from the adrenal gland to the blood.

00:21 Now, this corticosterone binds to intracellular receptors with the help of kidney cells and after binding.

00:31 These function as transcription factors by binding dna and activating gene expression.

00:39 So overall we have been given about the hormone corticosterone.

00:49 Now before going to the statements, we will know what are corticosterone.

00:55 These are 21 carbon steroid hormones of type corticosteroid and these are released from the cortex of adrenal gland.

01:26 Now coming to the statements, the first statement is corticosterone has a specific three -dimensional shape that is essential for a proper binding to its receptor.

01:40 The given statement is true because these corticosterons have a 21 carbon three -dimensional shape which is very helpful for binding to different kind of receptors present over the body.

02:01 Now coming to the second statement, it says corticosterone have indirect effects on cells that do not have corticosterone receptors.

02:11 These are so because these steroid hormones can bind to any kind of receptors although it does not contain any corticosterone receptors.

02:22 These are so because they help in many functions like activating gene and expression by binding to steroid receptors.

02:34 Proteins in the cytoplasm when activated, they also functions as factor that initiate transcritone...

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