In terms of tissue tropism, the Ebola virus has (A) tropism, and the rabies virus has (B) tropism.
Added by Robert T.
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Ebola virus primarily targets a wide range of cells including monocytes, macrophages, dendritic cells, endothelial cells, hepatocytes, and fibroblasts. This broad range indicates a **broad tissue tropism**. Show more…
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11. Ebola virus is a virus that is frequently and rapidly lethal in humans. The envelopes around particles of Ebola virus are studded with a viral glycoprotein (GP). Researchers hypothesized that, to enter a human cell, GP molecules must be cleaved by a protease enzyme, after which they bind with a protein called NPC1 in the human cell membrane. Reptile cells do not normally express the NPC1 protein, but the researchers modified some reptile cells to express NPC1. They then exposed the unmodified and modified cells to Ebola virus, both in the presence of a protease inhibitor that prevents GP cleavage, and without that inhibitor present. They then measured the frequency at which Ebola viruses infected the cells. These treatments are summarized below. I. Unmodified reptile cells, protease inhibitor absent II. Unmodified reptile cells, protease inhibitor present III. Modified reptile cells, protease inhibitor absent IV. Modified reptile cells, protease inhibitor present V. Unmodified human cells, protease inhibitor absent Which two groups should the researchers compare to test the hypothesis that NPC1 is necessary for infection?: * (A) I and II (B) I and III (C) I and V (D) II and IV
Supreeta N.
this question is based on the following: the EH virus binds to a receptor called IRL-1. Consider the data/table below: Receptor name | Mouse liver cell | Mouse pancreas cell | sheep liver cell | sheep pancreas cell | Cow liver cell | Cow pancreas cell IRL-1 | absent | absent | absent | present | absent | Present CR5 | Present | absent | Present | Present | Present | Absent CX9 | absent | present | Absent | Present | absent | Present MSR-6 | absent | absent | Absent | absent | present | Present Please answer the following based on the information above-1pt each. put the answer for a-c in the same textbox below this question, write the appropriate letter in front of your answer to each question. a. What is the host range of the EH Virus? b. What is the specificity of the EH Virus? c. Would you expect the biosynthesis step to occur in the mouse pancreas cell?
Madhur L.
David's doctor was concerned that his symptoms included prickling and itching at the site of the dog bite; these sensations could be early symptoms of rabies. Several tests are available to diagnose rabies in live patients, but no single antemortem test is adequate. The doctor decided to take samples of David's blood, saliva, and skin for testing. The skin sample was taken from the nape of the neck (posterior side of the neck near the hairline). It was about 6 mm long and contained at least 10 hair follicles, including the superficial cutaneous nerve. An immunofluorescent staining technique was used on the skin biopsy specimen to detect rabies antibodies in the cutaneous nerves at the base of the hair follicles. A test was also performed on a serum sample from David's blood to determine whether any antibodies for the rabies virus had been produced. Meanwhile, the saliva sample was used for reverse transcriptase-polymerase chain reaction (RT-PCR) analysis, a test that can detect the presence of viral nucleic acid (RNA). The blood tests came back positive for the presence of rabies virus antigen, prompting David's doctor to prescribe prophylactic treatment. David is given a series of intramuscular injections of human rabies immunoglobulin along with a series of rabies vaccines. Why does the immunofluorescent technique look for rabies antibodies rather than the rabies virus itself? If David has contracted rabies, what is his prognosis?
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