In the active site of DNA polymerase, there are multiple...

In the active site of DNA polymerase, there are multiple aspartate residues that help to coordinate ________. ? protons ? $Mg^{2+}$ ions ? triphosphate nucleosides ? hydroxyl ions ? inorganic phosphate

Please answer the following question about certain mechanistic aspects of DNA Pol. Ribonucleotide triphosphates (containing the sugar ribose) are at a much higher concentration in a cell than deoxyribonucleotide triphosphates (containing the sugar deoxyribose). Why doesn't DNA polymerase mistakenly add ribonucleotides to the growing DNA strand during DNA replication? The role of the divalent metal ions in the DNA polymerase active site is to change the chemical environment. List 2 ways the environment changes How do the divalent metals in RNA polymerases differ? The palm domain of DNA polymerase is also involved in proofreading newly synthesized DNA. What type of enzymatic activity is involved? (exonuclease or endonuclease) This enzymatic activity acts on which end of the growing strand? (3' or 5') Is DNA released from the polymerase during proofreading? (yes or no)

Sri K.

Question

In the active site of DNA polymerase, there are multiple aspartate residues that help to coordinate ________. ? protons ? $Mg^{2+}$ ions ? triphosphate nucleosides ? hydroxyl ions ? inorganic phosphate

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