In the body, what cellular function is the unaffected (no PKU) enzyme/protein associated with? Converts the amino acid phenylalanine to the amino acid tyrosine Converts the protein phenylalanine to the protein tyrosine Converts protein kinase a to protein kinase c Converts the nucleic acid methionine to the nucleic acid phenylalanine
Added by Brian B.
Step 1
This condition is caused by a deficiency in the enzyme phenylalanine hydroxylase. Show more…
Show all steps
Your feedback will help us improve your experience
Qudsiya Anis and 85 other Biology educators are ready to help you.
Ask a new question
Labs
Want to see this concept in action?
Explore this concept interactively to see how it behaves as you change inputs.
Key Concepts
Recommended Videos
Which enzyme is defective in PKU? (A) DOPA $\stackrel{\text { Enzyme(1) }}{\longrightarrow}$ Melanin (B) Tyrosine $\stackrel{\text { Enzyme(2) }}{\longrightarrow}$ Thyroxin (C) Phenylalanine $\stackrel{\text { Enzyme(3) }}{\longrightarrow}$ Tyrosine (D) Tyrosine $\stackrel{\text { Enyme(4) }}{\longrightarrow}$ Homogentisic acid (a) Enzyme (A) (b) Enzyme (B) (c) Enzyme (C) (d) Enzyme (D)
Phenylketonuria (PKU) is an inherited metabolic disorder caused by a deficiency of the enzyme phenylalanine hydroxylase. The enzyme breaks down the amino acid phenylalanine into tyrosine. Mutations in the gene coding for this enzyme can result in PKU. Different alleles of the gene can lead to varying levels of enzyme activity. Some alleles can cause complete loss of function, while others may result in reduced activity. There are also different mutations within the gene that can lead to different forms of PKU. Understanding the effects of these mutations on the encoded mRNA can provide insights into the disease.
Sri K.
What are the FOUR important characteristics of the genetic code? Dietary protein Thyroxine Phenylalanine Tyrosine DOPA PKU Albinism Phenylpyruvic acid p-Hydroxyphenyl-pyruvate Melanin 2,5-Dihydroxyphenyl: pyruvate Homogentisic acid (HA) Alkaptonuria Maleylacetoacetic acid CoztHzO Duapldtt Fn u# Refer to the above pathway. What effect, if any, would you expect PKU to have on melanin pigment formation? What effect, if any, would you expect Alkaptonuria (AKU) to have on melanin pigment formation?
Adi S.
Recommended Textbooks
Biology for AP Courses
Objective Biology for NEET
Introduction to General, Organic and Biochemistry
Transcript
Watch the video solution with this free unlock.
EMAIL
PASSWORD