In the research paper stratified genome wide association...

In the research paper "Stratified genome-wide association analysis of type 2 diabetes reveals subgroups with genetic and environmental heterogeneity" by Christiansen et al., discuss the following topics: How has each study enriched the field of population genomics? Include an investigation into the supplemental materials documents to your commentary. Do you have any critical or thoughtful comments to add?

Transcript

00:01 Hello everyone, in this question we are talking about the type 1 and type 2 diabetes and we have to answer a few questions related to them.

00:12 For example, the causes, the pathophysiology, then diagnosis followed by treatment and prognosis for both of them.

00:35 So the answer to this question is, so first of all we will talk about diabetes 1.

00:40 So this is known to have the cause of the autoimmune reaction where the immune system destroys the islet cells and prevent the production of insulin.

01:06 So this is the cause for type 1 diabetes.

01:08 Whereas in case of type 2 diabetes, it can have multiple different factors but the ultimate cause is less production of insulin and the body becoming resistant to insulin which means that the cell receptors do not respond to insulin.

01:37 Now we will come to the pathophysiology.

01:41 So when we are talking about the pathophysiology for type 1 diabetes, we are talking about the autoimmunity.

01:46 So the body develops autoimmune response against the insulin producing beta cells.

02:12 As for the type 2 diabetes, it can be reduced insulin production and resistance of cells against insulin.

02:31 Now both can have different multiple diagnosis tests.

02:35 For example, the fasting blood glucose test and as for diabetes 2, we have got the hemoglobin a1c test which measures the blood glucose for some time that is months to determine if it is consistently high or not...

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