00:01
Hello students in this question first we know that individuals with scid individuals who has scid has severe has lack of t cell lack of t cells that is severe coordinating severe that is important t cell which is important for immune response they have lack it so have severe immunodeficiency have severe immunodeficiency this is this is the fact the second is we are told that these individuals fail to make antibodies response to normal childhood vaccine fail to produce antibody against normal childhood vaccines so anti -based antibodies are produced by b cell, antibody produced by b cells.
01:37
So we need to consider why b cells might not be functioning properly in scid patient.
01:45
So option 1 is telling scid patient generally lack all the b cell.
01:56
If this were the case then they would not be able to produce antibodies at all.
02:03
Not just fail to respond the vaccine.
02:06
So therefore, this option is eliminate.
02:13
Option b is telling scid causes effect in the b cell receptor signaling.
02:25
B cell receptor are important for recognizing and binding the specific antigen, which then trigger the cell to produce antibodies.
02:35
If the b cell receptor signaling is defective, then the b cell would not be able to recognize and respond to antigens in vaccine.
02:45
So this option must be in consideration and it is explained that scid patient fails to respond to vaccine.
03:10
So option c is telling...