Individuals who have Edwards Syndrome have three copies of chromosome 18. This disorder is caused by: Group of answer choices a. Nondisjunction during meiosis b. Inappropriate entry into S phase c. Loss of the G1 checkpoint d. Failure of chromosomes to align during metaphase of mitosis during the first embryonic cell divisions
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Step 1: Edwards Syndrome is caused by individuals having three copies of chromosome 18. Show more…
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2. A child with Edwards Syndrome has the karyotype shown. Children born with this disease are small, cognitively impaired, and die as infants due to heart failure. a. What is abnormal about the karyotype? b. Circle a homologous pair of chromosomes on the karyotype. c. Draw anaphase 1 and anaphase 2 in a normal cell undergoing meiosis. Draw only chromosome #1 and the chromosome that is abnormal in Edwards Syndrome people (but here you are drawing a normal cell). Indicate homologous chromosomes by filling in the paternal copy and drawing the maternal copy just in outline. Pay attention to size and color. Include spindle fibers so that it is clear that the cell is in anaphase. normal anaphase 1 normal anaphase 2 d. Edwards Syndrome can result from an error in anaphase 1 or anaphase 2. Draw pictures that show an error in both anaphase 1 and anaphase 2 of meiosis that will result in a gamete that can lead to Edwards Syndrome. Include chromosome #1 and the chromosome that is abnormal in Edwards Syndrome patients. Indicate homologous chromosomes by filling in the paternal copy and drawing the maternal copy just in outline. Pay attention to size and color. Include spindle fibers so that it is clear that the cell is in anaphase. abnormal anaphase 1 abnormal anaphase 2
Madhur L.
The karyotype indicates a problem with chromosome 18. What is the problem and what is the BEST explanation for why it occurred? A) extra chromosome; insertion B) foreign chromosome; deletion C) extra chromosome; nondisjunction D) mutated chromosome; crossing over
Nondisjunction at meiosis can result in ___________. a. duplications b. aneuploidy c. crossing over d. pleiotropy
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