Intracellular Ca2+ levels are important in cardiac muscle. Increasing intracellular Ca2+ levels in heart muscle cells leads to an increase in muscle contraction. Lowering the intracellular Ca2+ levels decreases the strength of cardiac muscle contraction. Congestive heart failure can occur when the heart's pumping of blood is weaker than normal, which leads to fluid collecting around organs, including the heart. One treatment method is to give the patient drugs that increase the strength of the heart muscle contraction. Which of the following might function as an effective treatment of congestive heart failure by increasing the strength of heart muscle contraction? Choose one or more: A.a diuretic drug that triggers removal of excess Na+ from the body B.a drug that inhibits the Na+-K+ pump from establishing a strong Na+ gradient C.a drug that blocks the calcium channel in heart muscle cells D.a drug that decreases the activity of the Na+/Ca2+ transporter
Added by Jose Ignacio T.
Step 1
Congestive heart failure occurs when the heart's pumping is weaker than normal, leading to fluid accumulation. One treatment method is to give drugs that increase the strength of heart muscle contraction. Show more…
Show all steps
Your feedback will help us improve your experience
Sukhwinder N and 71 other Biology educators are ready to help you.
Ask a new question
Labs
Want to see this concept in action?
Explore this concept interactively to see how it behaves as you change inputs.
Key Concepts
Recommended Videos
The Na+Ca2+ exchanger is a bidirectional antiporter protein expressed in cardiac myocytes that removes calcium from the cytoplasm by exchanging it with sodium. Cardiac myocytes also express the Na+K+ ATPase. Suppose that a Na+K+ ATPase inhibitor (digoxin) is added to cardiac myocytes. Using your knowledge of the relative concentrations of ions (intracellular vs. extracellular) and the important role of the Na+K+ ATPase in maintaining the electrochemical gradient, what change would you expect in the intracellular [Ca2+]?
Tracy L.
During an action potential in a myocardial contractile cell, the membrane potential changes that occur are a result of _________. A. sodium influx through voltage-gated sodium channels during the rapid depolarization phase, and potassium efflux during the repolarization phase. B. potassium influx through voltage-gated potassium channels during the rapid depolarization phase, and sodium efflux during the repolarization phase. C. sodium influx through If channels, followed by calcium influx through voltage gated calcium channels during the depolarization phase, and potassium efflux during the repolarization phase. D. potassium influx through voltage-gated potassium channels that brings the membrane potential to threshold, followed by sodium influx through voltage gated sodium channels during the rapid depolarization phase, and potassium efflux during the repolarization phase. E. sodium influx through voltage-gated sodium channels through the depolarization phase, followed by potassium efflux through voltage gated potassium channels and calcium influx through voltage-gated calcium channels during the plateau phase, and potassium efflux during the repolarization phase.
Madhur L.
What causes the release of calcium ions from the sarcoplasmic reticulum? a. an increase in calcium ions within the T tubules b. the formation of cross-bridges c. an action potential d. contraction of a sarcomere
Recommended Textbooks
Biology for AP Courses
Objective Biology for NEET
Introduction to General, Organic and Biochemistry
Transcript
Watch the video solution with this free unlock.
EMAIL
PASSWORD