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QUESTIONS MENDELIAN GENETICS AND PROBABILITY 1. If two people with sickle cell trait have children, what is the chance that a child will have normal RBCs in both high- and low-oxygen environments? What is the chance that a child will have sickle cell disease? Write the possible genotypes in the Punnett square. Normal RBCs in high- and low-oxygen environments Sickle cell disease a. What is the chance that a child will carry the HbS gene but not have sickle cell disease? b. What are the chances that these parents will have three children who are homozygous for normal RBCs? (Show your work.) c. What are the chances that these parents will have three children who have both normal and mutant hemoglobin beta chains? (Show your work.) d. What are the chances that all three of their children will show the disease phenotype? (Show your work.) e. What are the chances that these parents will have two children with sickle cell trait and one with sickle cell disease? (Show your work.) f. In the cross above, if you know that the child does not have sickle cell disease, what is the chance that the child has sickle cell trait?

          QUESTIONS
MENDELIAN GENETICS AND PROBABILITY
1. If two people with sickle cell trait have children, what is the chance that a child will have normal RBCs in both high- and low-oxygen environments? What is the chance that a child will have sickle cell disease? Write the possible genotypes in the Punnett square.

Normal RBCs in high- and low-oxygen environments ______

Sickle cell disease ______

a. What is the chance that a child will carry the HbS gene but not have sickle cell disease? ______
b. What are the chances that these parents will have three children who are homozygous for normal RBCs? (Show your work.) ______
c. What are the chances that these parents will have three children who have both normal and mutant hemoglobin beta chains? (Show your work.) ______
d. What are the chances that all three of their children will show the disease phenotype? (Show your work.) ______
e. What are the chances that these parents will have two children with sickle cell trait and one with sickle cell disease? (Show your work.) ______
f. In the cross above, if you know that the child does not have sickle cell disease, what is the chance that the child has sickle cell trait? ______

QUESTIONS
MENDELIAN GENETICS AND PROBABILITY
1. If two people with sickle cell trait have children, what is the chance that a child will have normal RBCs in both high- and low-oxygen environments? What is the chance that a child will have sickle cell disease? Write the possible genotypes in the Punnett square.

Normal RBCs in high- and low-oxygen environments

Sickle cell disease

a. What is the chance that a child will carry the HbS gene but not have sickle cell disease?
b. What are the chances that these parents will have three children who are homozygous for normal RBCs? (Show your work.)
c. What are the chances that these parents will have three children who have both normal and mutant hemoglobin beta chains? (Show your work.)
d. What are the chances that all three of their children will show the disease phenotype? (Show your work.)
e. What are the chances that these parents will have two children with sickle cell trait and one with sickle cell disease? (Show your work.)
f. In the cross above, if you know that the child does not have sickle cell disease, what is the chance that the child has sickle cell trait?

Added by Jeremy A.

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