00:01
We have a ton to write in this one.
00:03
A 48 -year -old romanian male with a recent diagnosis of an unknown disease presents to a doctor in the u .s., complaining of severe abdominal pain, erectile dysfunction, and urine, which has gradually become significantly darker over the past few days.
00:19
He also states that in addition to the aforementioned systems, he also has, severe shortness of breath, fatigue, and loss of appetite.
00:28
Labs were revealing of a hemogloment of 6 .5.
00:31
Normal's 12 to 16.
00:33
Unconjugated bilirubin of 12 .3, which is significantly elevated, with all the labs, returning is unremarkable.
00:41
His vitals were notable for a blood pressure of 99 over 64, heart rate of 120, respiratory rate of 33 and oxygen saturation, 88 % on room air.
00:53
Further testing revealed the diagnosis of peroxysmal nocturnal hemoglobinuria, urea.
00:59
Which of the following is the most likely pathophysiological mechanism underlying this disease? i'm just writing.
01:48
And we are given the following.
01:51
Defect in c .d.
01:57
59.
02:03
Deficiency in vitamin b12.
02:13
A defect in cd21.
02:22
A defect in c3, vertase or.
02:33
Excessive iron...