00:01
Hello all, so here the question is that at what stage of b cell differentiation, b cell differentiation, it defines the more immunocompetent b lymphocyte, immunocompetent b lymphocyte, immunocompetent b lymphocyte.
00:29
So, when we are analyzing this question, the first thing that b lymphocyte arise from the stem cells or bone marrow.
00:35
So, first we should know that where it originates.
00:38
So, it originates from the bone marrow, the stem cells of bone marrow and mature in the lymphoid organ, mature in lymphoid organs.
00:50
And the stage in b cell differentiation that defines an immunocompetent b cell is when it expresses a functional b cell receptor that is bcr on the surface.
01:01
So, when it expresses, expresses the functional b cell receptor, functional b cell receptor.
01:20
So, this will be the answer for the first thing.
01:23
And the next it asks that the m cells are specialized epithelial cells in the pate patches, m cells and how the lumen play immunity.
01:38
So, for the answer for the second one, the m cells are in the pate patches are present in the epithelial cells or they are specialized epithelial cells, epithelial cells that present in the pate patches, pate patches.
02:11
And the role of immunity is to transport antigen from the gut lumen to the immune cells.
02:17
So, they transport the antigens.
02:25
So, they included in transportation of antigens from gut lumen, gut lumen into the underlying immune cell, into the underlying immune cells.
02:49
So, this is the function of the m cells.
02:52
And third thing about the monoclonal antibodies...