Macrolide resistance can be caused by A. Modification mechanism comprises of methylation on the 23S rRNA by the Erm family of methyltransferases, encoded by the erythromycin ribosome methylase gene B. Inactivation by AG-modifying enzymes C. Mutations at nucleotide A2058 within the 50S ribosomal subunit also confer macrolide-resistance D. Structural mutation coupled with $\beta$-lactamase production and the ability of the pathogen to produce hydrolysis enzymes
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Match the mechanism of antimicrobial drug resistance to its best description: - drug inactivation - modification of drug binding site - preventing accumulation of drug inside cell - biofilm formation A. enzyme cleaves Ě -lactam ring in penicillin B. Extracellular polysaccharides produced in complex ecosystem of microorganisms slows diffusion of antimicrobial drug C. Efflux pump pumps antibiotic out of cell D. a point mutation in rRNA gene changes shape of ribosome such that streptomycin can no long bind to ribosome
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