MHC restriction is best described as: a. elimination of thymocytes bearing T-cell receptors that are unable to interact with self-MHC molecules b. preferential survival and proliferation of thymocytes that survive negative selection c. T-cell recognition of a peptide antigen only when it is bound to a particular form of MHC molecule d. a state of non-responsiveness to a peptide antigen e. a condition in which either MHC class I or class II molecules are not expressed on cells.
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Step 1: MHC restriction refers to T-cell recognition of a peptide antigen only when it is bound to a particular form of MHC molecule. Show more…
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Which one of the following statements about MHC-TCR interactions is NOT true? A. Antigen receptors on T cells bind to MHC molecules for only brief periods of time. B. The affinity of most TCRs for peptide-MHC complexes is similar to the affinity of antibodies for their antigens. C. Only 1% or less of the MHC molecules on any antigen-presenting cell (APC) display a peptide recognized by a particular T cell. D. T cells usually require multiple engagements with an APC before a threshold of activation is reached. E. A subthreshold number of MHC-TCR interactions can lead to T cell inactivation.
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Class I MHC molecules are associated with: a. all T cells b. B cells c. CD4 cells 2. Cells that possess receptors that react very strongly with self proteins must be eliminated in order to prevent autoimmune reactions. This is referred to as: a. lymphopoiesis b. negative selection c. positive selection d. apoptosis e. anergy 3. The clinical test to diagnose allergy in which a serum sample is taken from a patient and tested in-vitro on a solid support system is called: a. PRIST b. RAST c. RFLP d. PCR e. Desensitization 4. Breakdown of self-recognition leads to: a. immunodeficiency b. autoimmunity c. allergies d. HLA restriction e. none of the above f. CD8 cells g. T regulatory cells
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The major histocompatibility complex (MHC) (a) consists of Y-shaped molecules (b) encodes certain antibodies (c) encodes Toll-like receptors (d) inhibits complement release from macrophages (e) encodes a group of cell-surface proteins.
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