MicroRNAs bind to the 3' ends of specific mRNAs to silence them. the 5' ends of specific rRNAs to silence them. the 3' ends of specific tRNAs to silence them. the 4' ends of specific mRNAs to silence them.
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Step 1: Recall that microRNAs regulate gene expression by binding to the 3' untranslated regions (3' UTRs) of target mRNAs to silence them. Show more…
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In RNA silencing, siRNAs and miRNAs usually bind to which part of the mRNA molecules that they control? a. 5’ UTR b. Coding region c. 3’ poly(A) tail d. 3’ UTR
Adi S.
MicroRNAs are small RNA molecules that bind to the $3^{\prime}$ end of mRNAs and suppress trandation (see Chapter 14). How miRNAs suppress translation is still being investigated. Some eukaryotic mRNAs have internal ribosome-binding sites downstream of the $5^{\prime}$ cap, where ribosomes normally bind. In one investigation, miRNAs did not suppress the translation of ribosomes that attach to internal ribosome-binding sites (R. S. Pillai et al. 2005. Science $309: 1573-1576$ ). What does this finding suggest about how miRNAs suppress translation?
In the RNA silencing pathway, the RISC protein complex acts by blocking translation of specific mRNAs. RISC targets mRNAs that have a sequence that is complementary to a microRNA guide strand. RISC targets mRNAs that are highly methylated.
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