Mitochondria harness the proton gradient across the inner membrane to generate ATP. The pH gradient generates a membrane potential of -60 mV. The synthesis of one molecule of ATP requires 3 protons to pass through the F0/F1 ATPase. If the ATP/ADP ratio in the matrix is 1:5, the Pi concentration is 2 mM, and the matrix pH is 7.0, what must the pH be in the space to generate one molecule of ATP at 37°C? ΔG° = 7.3 kcal/mol for ATP synthesis.
Added by Trinidad J.
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98 cal/mol*K), T is the temperature in Kelvin (37°C = 310 K), and Q is the reaction quotient. Show more…
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A mitochondrial membrane complex consisting of ATP synthase, adenine nucleotide translocase (ATP-ADP translocase), and phosphate translocase functions in oxidative phosphorylation. Adenine nucleotide translocase, an antiporter located in the inner mitochondrial membrane, moves ADP into and ATP out of the matrix. Phosphate translocase is also located in the inner mitochondrial membrane. It transports H+ ions and phosphate H2PO4- ions into the matrix. The energy derived from the movement of H+ ions down an electrochemical gradient from the intermembrane space into the matrix is used to drive the synthesis of ATP. How many H+ ions must be moved into the matrix for the synthesis of 1 ATP? number of H+ ions: per ATP
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