Mitochondrial porins are a family of proteins responsible for membrane transport of several metabolites. Porins share a common structural motif known as \beta barrels, which is comprised of several \beta sheets oriented to form a central path, or pore, for metabolites to be transported across lipid bilayer membranes (illustrated to the right) What feature of \beta sheets makes this arrangement favorable given the localization of porins? image shows membrane and then an antiparallel beta sheets next to it
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This transport is crucial for the proper functioning of cellular respiration and energy production. Show more…
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What is unique about porins, compared to most other integral membrane proteins? a. They have a $\beta$ -barrel motif, which allows them to make water tunnels in membranes. b. Their transmembrane domains are composed largely of $\alpha$ helices. c. Their transmembrane domains contain a high percentage of hydrophilic amino acids. d. They have a single transmembrane domain, which loosely anchors them into the membrane.
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There is a type of protein that is made of beta sheets called "beta barrels". The beta-barrel structure is beta-sheet strands in a barrel-shaped structure. These types of protein structures are commonly found in pore proteins (porins) which are embedded in the cell membrane. Pore proteins are often involved in moving molecules across the cell membrane such as ions or water through the "pores" or the middle of the barrel-shaped protein structure. Can you predict how the amino acids in the beta-sheet in this protein would be arranged with respect to the outside of the "barrel" and the inside of the "barrel" in terms of the chemistry of the R groups in the beta-sheet? Would this differ from a soluble globular protein found floating in the cytosol? Why or why not? Include in your answer a discussion of how adjacent R groups are arranged in beta-sheets.
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The outer membrane contains a large pore-forming protein called . The machinery needed for aerobic respiration and ATP formation is called . ATP synthase particle Porin Inner membrane Outer membrane Intramembrane space Cristae Matrix Intermembrane space
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