Malonate is a competitive inhibitor of succinate dehydrogenase. If malonate is added to a mitochondrial preparation that is oxidizing pyruvate as a substrate, which of the following compounds would you expect to decrease in concentration? succinate fumarate isocitrate citrate pyruvate
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Extra Credit (2pts): Malonate is a competitive inhibitor of succinate dehydrogenase. If malonate is added to a mitochondrial preparation that is oxidizing pyruvate as a substrate, what metabolite would you expect to decrease in concentration?
Sri K.
Malonate acts as a competitive inhibitor of succinate dehydrogenase by competing with succinate. If malonate is added to a mitochondrial preparation that is oxidizing pyruvate as a substrate, the compound for which you would expect to see the most immediate decrease in concentration is . However, you could reverse this deficiency most directly (without involving other steps of the citric acid cycle or other metabolic pathways) by adding an excess of intermediates or to the preparation.
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