00:01
Hello student, here the question is given and the question is regarding this transmembrane receptor.
00:08
So, in this transmembrane receptors there are the, we can say these are the receptor which are embedded in the plasma membrane that's why the name is the transmembrane.
00:19
So, these are the embedded in the plasma membrane or the cell membrane.
00:26
So, mainly they act in as a signaling cascade.
00:36
So, only by the binding of these ligand to the transmembrane receptor, so suppose these kind of transmembrane receptor is present inside the cell membrane, so when the ligand is going to be, so this is the ligand and this is the receptor which is the transmembrane one.
00:55
So, after binding with the ligand there is a series of reaction which taking place inside this internal domain.
01:03
So, after binding this, the specialized one is going to be allow communication between the, from outside of the cell or extracellular space to the inside of the cells.
01:15
So, in that case if suppose it is a gtp binding protein, so initially it is going to bind with the gtp and after binding with this ligand it is going to be active by the binding with this gtp.
01:30
So, this chemical changes need to be happen in order to activate these several pathway and this is the signaling cascade is activated.
01:40
So, whether it could be activation of gene or the repression of gene, both are done by the these internal domain modification.
01:52
So, if the by binding with this ligand these internal domain modification is taking place...