Multiple choice: NRF2 is a transcription factor that is required to induce anti-oxidant genes, such as glutathione-S-transferase genes, in response to reactive oxygen and reactive nitrogen species released by inflammatory cells in the airways following phagocytosis of inhaled particles. Mice deficient in Nrf2 were tested for their allergic airway response to inhaled allergens in comparison to wild-type controls. Compared to wild type mice, the Nrf2-/- mice would be expected to show: A. Reduced recruitment of eosinophils to the airway mucosa B. Enhanced production of IL-17 and IL-22 required to repair damaged epithelium C. Increased levels of IL-4 and IL-13 in the airway D. Increased numbers of CD4 Treg cells in the airway epithelium E. Reduced levels of allergen-specific IgE
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Nrf2 is a transcription factor that induces anti-oxidant genes in response to reactive oxygen and nitrogen species. This response is crucial for protecting cells from oxidative stress caused by inhaled particles. Show more…
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