Neural Tissue LAB ACTIVITY 4: Neurophysiology. Conduction of information in the form of a nerve impulse starts and ends with release of neurotransmitter molecules at synapses. Indicate the order in which the following events occur at synapses on dendrites & the cell body: ____ Calcium influx causes exocytosis of neurotransmitter from presynaptic membrane. ____ Ligand-gated ion channels on postsynaptic membrane open, leading to graded changes in membrane potential. ____ Nerve impulse arrives at axonal terminal. ____ Neurotransmitter diffuses across synaptic cleft and binds receptors on postsynaptic membrane. ____ Neurotransmitter effects are terminated by reuptake, diffusion, or enzymatic degradation. ____ Voltage-gated Ca2+ channels open and allow Ca2+ ions to enter axon terminal. 1.2 Pts. Indicate the order in which the following events occur as an action potential is generated and propagates down the axon: ____ Membrane potential at axon hillock reaches threshold. ____ Na+ gates close AND voltage-gated K+ channels open. ____ Efflux of K+ ions repolarizes, then hyperpolarizes membrane. ____ Na+ - K+ pumps & leakage channels re-establish resting membrane potential. ____ Voltage- gated Na+ channels open. ____ Influx of Na+ ions depolarizes membrane. 1.2 Pts.
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During cell to cell communication at the synapse the correct sequence of events is: a. 1) Action potential arrives at axon terminal 2) Exocytosis is triggered by K+ entry 3) Voltage gated K+ channels open 4) Neurotransmitter is released into the synaptic cleft 5) Neurotransmitter binding initiates a response in the postsynaptic cell b. 1) Action potential arrives at axon terminal 2) Voltage gated Ca2+ channels open 3) Exocytosis is triggered by Ca2+ entry 4) Neurotransmitter is released into the synaptic cleft 5) Neurotransmitter binding initiates a response in the postsynaptic cell c. 1) Action potential arrives at axon terminal 2) Voltage gated K+ channels open 3) Exocytosis is triggered by K+ entry 4) Neurotransmitter is released into the synaptic cleft 5) Neurotransmitter binding initiates a response in the postsynaptic cell d. 1) Action potential arrives at axon terminal 2) Exocytosis is triggered by Ca2+ entry 3) Voltage gated Ca2+ channels open 4) Neurotransmitter is released into the synaptic cleft 5) Neurotransmitter binding initiates a response in the postsynaptic cell e. 1) Action potential arrives at axon terminal 2) Voltage gated Na+ channels open 3) Exocytosis is triggered by Na+ entry 4) Neurotransmitter is released into the synaptic cleft 5) Neurotransmitter binding initiates a response in the postsynaptic cell
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