00:01
This is about nicotinic receptors, all right? this is nicotanic receptors, and these are perfectly shaped as cylindrical receptors, okay? so, like, they're cylindrical in shape, right? in shape and also their proteins, of course, receptors are proteins.
00:26
And they are found embedded in the synaptic walls, okay? that and these walls act as you know kind of chemically controlled sodium ion channels all right and also you can call these very interesting tammya numalustin a neurology known as ligand -gated sodium channels all right so you can call this link at ligand gated sodium channel right because these channels penetrate through the cells of post -synaptic uh post -synaptic uh of the skeletal neuromuscular c junctions right so we're talking about skeletal neuromuscular junctions right and you need to understand that this nicotinic receptor is to the key function is to trigger rapid neuron and neuromuscular transmission okay so it's to trigger rapid uh neuron plus uh neuromuscular transmissions you understand that right so we can also come up with uh this illustration as i can i can add the diagram to help us understand this structure of nicotinic receptor.
02:21
So this is the nicotinic receptor, as you can see here, right? and then this is when the channel is closed.
02:30
This is the perfect illustration of a cell membrane.
02:33
Acetylcholine is the neurotransmitter chemical substance that burns here, not epineapherine, right? so it's acetylcholine, right? and then once the acetacoline binds to this receptor, right, the sodium ion gated channel opens.
02:50
You see channel opens here, right? and now sodium can pass through, especially when signals is initiated there, right? so we are saying that when acetacoline attaches to the portion of the nicotinic receptor outside the cell membrane here.
03:11
You can see that right what happens is that it induces a conformational change which selectively opens up the channel to sodium ions as you can see okay and these results to influx of positively charged sodium ions which then triggers membrane polarization okay so this is membrane polarization that results here right and what happens after polarization is the opening of another trans membrane channels which are the sino selectively allows for the flow of either ion like potassium into the cell.
03:48
Okay...