Now diagram the flow of events (leading to the release of cortisol and T3/T4 respectively): a) When body temperature drops below 36.8 degree Celsius OR b) When an event triggers the long-term stress response leading to partial suppression of the immune system. Describe the series of events, using the numbers in the drawing (for example: "which travels through 6. Blood vessel to 7. ______") As many other hormones, cortisol and thyroid hormone levels are under negative feedback regulation. a) Suggest sites in your figure that could control cortisol and thyroid hormone levels b) Suggest signal molecules that could be used to trigger stopping production of these hormones. c) How would this signal be translated into a cellular response such as stopping hormone production?
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When body temperature drops below 36.8 degrees Celsius, the hypothalamus detects the change and releases thyrotropin-releasing hormone (TRH). Show more…
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Madhur L.
The diagram shows the normal feedback loop that controls the production of thyroid hormones in the human body. Graves’ disease is an autoimmune disease in which the body produces autoantibodies to the TSH receptor. When these autoantibodies bind to the receptor, it mimics the action of the TSH hormone. How would the feedback loop and the regulated production of thyroid hormones shown in the diagram be affected in a person with Graves’ disease? a. The feedback loop would be disrupted. Autoantibodies would bind to the TSH receptors, allowing them to continue to produce thyroid hormones. As a result, there would be an overproduction of thyroid hormones because the negative feedback system would be unable to function. b. The feedback loop would be not be disrupted. Autoantibodies would bind to the TSH receptors, allowing them to continue to produce thyroid hormones. As a result, there would be an overproduction of thyroid hormones because the negative feedback system would be unable to function. c. The feedback loop would be disrupted. Autoantibodies would not bind to the TSH receptors, allowing them to continue to produce thyroid hormones. As a result, there would be an overproduction of thyroid hormones because the negative feedback system would be unable to function. d. The feedback loop would be disrupted. Autoantibodies would bind to the TSH receptors, allowing them to continue to produce thyroid hormones. As a result, there would be an overproduction of thyroid hormones because the negative feedback system was functional.
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