00:01
The question that is given over here, this is regarding the mutation.
00:06
The question is, one unexpected result of sequencing human genome was the finding that mutations in single gene can be responsible for multiple distinct disorders.
00:18
For example, mutations in ret gene can cause two different types of multiple endocrine neoplasms, family and thyroid cancinoma and hirtsprung disease.
00:31
Over here, we have to determine how do we think mutations in single gene can have such diverse effects.
00:40
A single gene generally produces different proteins and single protein contains several amino acid.
00:54
If a single amino acid is changed from original sequence, then this can lead to non -functional protein, overactive protein or entirely different protein.
01:10
The amino acid can be changed due to the mutation in the dna sequence.
01:19
Mutation in single gene can be of different types like the insertion, deletion, substitution of single nucleotide as seen in point mutation or it can be chromosomal mutation which involves the change in chromosome...