Pemphigus is an autoimmune blistering skin disease in whcih keratinocytes in the epidermins lose cell-to-cell adhesion. Which transmembrane proteins are likely targeted by antibodies to cause this condition? Integrins O Connexins O Cadherins O Claudins and occuldins
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You have learned that there are many cell-cell junctions in most cell types. Prominent in squamous epithelium such as skin are desmosomes, adherens junctions and hemidesmosomes. There is a very serious disease called pemphigus vulgaris which is an autoimmune disorder whereby the body makes antibodies against the transmembrane components of the desmosomes. The result is extensive blistering of the skin and, in severe cases, can lead to death. A. What is the role of desmosomes in the skin and how are these structures different from adherens junctions? B. Thinking about these two types of junctions and the fact that the autoantibodies produced only attack the desmosomes speculate as to why an epithelial sheet might need both adherens junctions and desmosomes to avoid blistering.
Adi S.
Diseases in humans that have a clinical presentation of severe and extensive blistering of the skin can result from defects in many (or any) components of desmosomes and hemidesmosomes or even proteins that function as cytoskeletal cross-linkers. Which of the following is unlikely to be defective in blistering diseases? A. keratin (a cytosolic IF protein) B. plectin (a linker of intermediate filaments [IFs] to other IFs) C. desmoglein (a cadherin, a cell adhesion molecule) D. lamin (a nuclear IF protein)
Danielle A.
Shaiju T.
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