Pernicious anemia is associated with a and c neurological symptoms gastric cancer decrease iron absorption
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Step 1: Pernicious anemia is a type of anemia that occurs when the body can't absorb enough vitamin B12. Show more…
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A 60-year-old man comes to the physician because of a 6-month history of light-headedness, numbness and paresthesias of his hands and feet, and fatigue. Physical examination shows pallor and decreased positional and vibration senses. Laboratory studies show: Hemoglobin: 9 g/dl Hematocrit: 27% Mean corpuscular volume: 102 ÎĽm3 Serum Gastrin: markedly increased Intraluminal stomach acid: markedly decreased The most likely cause of this patient's symptoms is destruction of which of the following areas in the normal stomach mucosa?
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Mr. X, age 57, presented to his physician with marked fatigue, nausea with occasional diarrhea, and a sore, swollen tongue. Lately he also has been experiencing a tingling feeling in his toes and a feeling of clumsiness. Microscopic examination of a blood sample indicated a reduced number of erythrocytes, many of which are megaloblasts, and a reduced number of leukocytes, including many large, hypersegmented cells. Hemoglobin and serum levels of vitamin B12 were below normal. Additional tests confirm pernicious anemia.Relate the pathophysiology of pernicious anemia to the manifestations listed above.Discuss how the gastric abnormalities contribute to vitamin B12 and iron deficiency and how vitamin B12 deficiency causes complications associated with pernicious anemia.Discuss other tests that could be performed to diagnose this type of anemia.Discuss the treatment available and the limitations.
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A lack of intrinsic factor, leading to a deficiency of vitamin B12 and large cells called Macrocytes is characteristic of:
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