Pharmaceutical companies carry out renal clearance studies on the drugs they can develop the information is very important for establishing dosing, regimens how often drugs need to be taken what does the term renal clearance refer to?
Added by Diane C.
Step 1
Step 1: Renal clearance refers to the rate at which a drug is removed from the body by the kidneys through urine. Show more…
Show all steps
Your feedback will help us improve your experience
Madhur L and 62 other Biology educators are ready to help you.
Ask a new question
Labs
Want to see this concept in action?
Explore this concept interactively to see how it behaves as you change inputs.
Key Concepts
Recommended Videos
Renal clearance of the drug CLR = GFR x funbound + Tubular secretion - Tubular reabsorption fu is the unbound fraction of drug Glomerular filtration rate is measured using endogenous creatinine: GFR ≈ creatinine clearance = 100 - 150 ml/min 1/ CLR > GFR x funbound : filtration + Tubular secretion 2/ CLR < GFR x funbound : filtration - Tubular reabsorption 3/ CLR ≈ GFR x funbound : filtration
Madhur L.
Explain how filtration, secretion, and reabsorption affect the renal plasma clearance of a substance. Use this information to explain how Inulin can be used to measure the GFR.
Drug X binds to plasma protein (fu= .7) and has a total clearance of 500 min/ml with 75% of the dose excreted unchanged. What is the renal clearance? What is the non-renal clearance?
Adi S.
Recommended Textbooks
Biology for AP Courses
Objective Biology for NEET
Introduction to General, Organic and Biochemistry
Transcript
18,000,000+
Students on Numerade
Trusted by students at 8,000+ universities
Watch the video solution with this free unlock.
EMAIL
PASSWORD