00:01
Okay, i want to answer this question, we have to talk about the anti -warmer equilibrium.
00:03
Remember that according to that, p plus q is equal to 1, where p is the frequency of alleles, alleles, okay, okay? alleles in a population that are dominant, dominant alils, while q is the frequency of alleles in a population that are recessive.
00:25
Also, we have that p -square plus 2 p -q plus u -square is 1, where p squared is equal to the frequency of individuals, individuals in a population that are homozygous dominant, 2 pq is the frequency of individuals in a population that are heterocygose, and q squared is the frequency of individuals in a population that are homozygous recessive.
00:59
So this question says, pheniacetonuria or pqau is a severe form of mental adaptation due to a program autosomal excessive a deal.
01:08
So, practically those with a disease are going to have this genotype here, homocygoseoseph.
01:14
Those with the heterocygosegene, genotype are going to be caggars, and those with the genotype homozygoyal dominant are going to be healthy people, practically, okay? it says about 1 in 16 ,000 newborn caucasians are affected with the disease.
01:29
So practically you have that 1 out of 16 ,000, it's going to be qs square because of this, okay, because those are going to be affected by the disease.
01:42
So just divide this and you're going to get, you're going to get a number that is qsquare is equal to 0 .000000625.
01:52
Okay, then you get good square.
01:54
You apply good square at both sides and you're going to get approximately you're going to get a value of u is equal to 0 .00, 7905, and so on.
02:07
Okay, but if you go out this, you're going to get 0 .008...