Phenylketonuria (PKU) is a human hereditary disease resulting from the inability of the body to process the chemical phenylalanine, which contained in the protein that we eat. PKU is caused by a autosomal recessive allele with simple Mendelian inheritance. A normal couple intends to have children but consult a genetic counselor because the man has a sister with PKU and the woman has a brother with PKU. There are no other known cases in their family. They want to know: 1. What is the probability that their first child would be normal? 2. What is the probability that their first two children would have PKU? 3. If they would like to have five children, what is the probability that all them would be normal?
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Phenylketonuria (PKU) is one of the most common inherited disorders — occurring in approximately 1 in 10,000 babies born in the U. S. It occurs in babies who inherit two mutant genes for the enzyme phenylalanine hydroxylase. This enzyme normally starts the process of breaking down molecules of the amino acid phenylalanine that are in excess of the body's needs for protein synthesis. In the United States, approximately 1 person in 50 has inherited a PKU allele. This means that some 5 million people in the U.S. are "carriers". Two individuals that did not have Phenylketonuria had two children. They had one child who inherited phenylketonuria and another child that did not have the disease. If they have a third child, what is the probability that that child will have PKU? 50% 25% 67% 100% 75%
Adi S.
Phenylketonuria (PKU) is a recessive disorder that can be treated with a diet very low in the amino acid phenylalanine. Jamie and his mother both have normal metabolism, whereas Jamie's father and sister both have PKU. Determine the genotypes for Jamie, Jamie's mother, Jamie's father, and Jamie's sister. Draw a Punnett square. (6 marks) If Jamie's parents have another child, what is the probability that this child will have PKU? (6 marks) If Jamie marries a woman who is a carrier for the PKU allele, what is the probability that their first child will have this recessive autosomal disease? Draw a Punnett square. (4 marks)
Andrew M.
Phenylketonuria (PKU) is an inherited disease caused by a recessive allele. If a woman and her husband are both carriers, what is the probability of each of the following? i. all three of their children will be of normal phenotype ii. one or more of the three children will have the disease iii. all three children will have the disease iv. at least one child will be phenotypically normal Show your work
Anand J.
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