The two most important cytokines that act as signal 3 for molding a newly activated naive CD4+ T cell into Th1 cells are: - IL-4 and IL-13 - IL-6 and TGF-beta - IL-1 and TNF - IL-17 and IL-22 - IL-12 and IFN-gamma Binding of a cytokine to a JAK-associated receptor on a newly activated CD4+ T cell activates STAT6, which upregulates the expression of the GATA-3 transcription factor. This, in turn, controls the differentiation of that cell. What kind of T helper cell will this cell become? - Th1 - Th2 - Th3 - Th17 - Tfh
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Binding of a cytokine to a JAK-associated receptor on a newly activated CD4+ T cell activates STAT6 which upregulates the expression of the GATA-3 transcription factor which in turn controls the differentiation of that cell. This cell will become a Th2 helper Show more…
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CD4+ T cells recognize a. both MHC class I and class II peptides. b. IgM. c. MHC class I peptides. d. MHC class II peptides. e. CD8+ markers. CD8+ T cells exposed to MHC class I peptides are a. dendritic T cells. b. both cytotoxic T cells and helper T cells. c. cytotoxic T cells. d. helper T cells. e. natural killer cells. A naïve T-cell refers to a T cell that a. resides in the thymus. b. is not mature. c. has not left the bone marrow. d. has not yet encountered an antigen. e. does not express CD4+ or CD8+. What event initiates an adaptive immune response? a. The production of MHC class I or II molecules b. The expression of cytokines CD4 or CD8 c. The interaction of a B cell with a TH cell d. The phagocytosis of a pathogen by a macrophage e. The interaction of a naive T cell with an antigen-presenting cell
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