point Which anti-inflammatory drug has a lower risk of causing gastrointestinal bleeding compared to other anti-inflammatory drugs ibuprofen celecoxib naproxen aspirin
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COX-2 inhibitors have been shown to have a lower risk of causing gastrointestinal bleeding compared to other anti-inflammatory drugs, such as ibuprofen, naproxen, and aspirin. Show more…
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Question 4c) Suppose that only 6% of the Celebrex subjects reported ulcers, while the rates for the ibuprofen and diclofenac patients were 18% and 16%, respectively. How many Celebrex patients reported ulcers? Here is the story behind the question: Celebrex is the third in a family of popular prescription painkillers to be linked to a higher incidence of heart attacks. This followed the September 30, 2004 removal of Vioxx from the market and the later revelation that Bextra also presents an increased health risk. Celebrex, Vioxx, and Bextra all work by inhibiting a protein called COX-2 that has been linked to inflammation. Celebrex and Vioxx were both introduced in 1999 and instantly became top-selling drugs for Merck and Pfizer, respectively. Pfizer, the world's largest drug maker, introduced Bextra in the United States in 2001, also to robust sales. While Merck removed Vioxx from the market, as of the end of 2004, Pfizer has been reluctant to follow suit with its COX-2 products. The company has insisted after the removal of Vioxx that its Celebrex was safe and it has continued to advertise and market the drug. One of the earlier studies involving Celebrex was reported in the September 13, 2000 issue of the Journal of the American Medical Association (Web site www.jama.com). Three anti-inflammatory drugs were tested to compare the gastrointestinal (GI) side effects. A summary of this study was given in the December 5, 2000 edition of the Orlando Sentinel under the section entitled "Quick Study: Updates on Major Health Topics." The article reports that of the nearly 8000 arthritis patients, half took celecoxib (brand name Celebrex), a pain reliever called a COX-2 inhibitor. The other half took either ibuprofen or diclofenac—conventional nonsteroidal anti-inflammatory drugs (NSAIDs) commonly used for arthritis. NSAIDs can lead to gastrointestinal (GI) problems. In this study, patients taking celecoxib were less likely to get ulcers than those taking standard daily doses of the NSAIDs.
Adi S.
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M.R. is a patient who takes glyburide for diabetes, lisinopril for HTN, Paxil for depression, and ibuprofen for arthritis. His blood sugar is still too high, and he is having pain in his knees. A new physician prescribes Glucophage and Celebrex. Which of the following medications would be considered a therapeutic duplication for one of the newly prescribed medications? Choose AnswerA celecoxib Choose AnswerB None. They are all fine to use together. Choose AnswerC paroxetine Choose AnswerD Zestril
Danielle F.
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