Prior to administering pyridostigmine to a client newly...

Prior to administering pyridostigmine to a client newly diagnosed with myasthenia gravis, the nurse provides education about adverse effects. Which of the following are manifestations of cholinesterase inhibitor toxicity? (Select the TWO that apply) Prior to administering pyridostigmine to a client newly diagnosed with myasthenia gravis, the nurse provides education about adverse effects. Which of the following are manifestations of cholinesterase inhibitor toxicity? (Select the TWO that apply) Muscle stiffness Blurry vision Urinary retention Respiratory depression Increased heart rate

Transcript

00:01 Okay, this question here says, you are a teaching physician working at a hospital.

00:03 Your patient is 30 years old who has been suffering from weak muscles.

00:07 Lately, they have been having difficulty breathing and swallowing.

00:10 After a blood test, you confirm that the patient is suffering from myasthenia gravis, which occurs when the immune system targets the acetylcholine receptors on the muscles of the colima, reducing the number of receptors.

00:20 You prescribe the patient pyridoctamine, which is a molecule that inhibits acetylcholine esterase, that is the enzyme that breaks down acetylcholine.

00:27 Calling and you as a resident physician to explain the diagnosis and the prescription here is the student responses or the student response okay so you have here um you have many many statements okay and it says choose the answers that are incorrect in the resident physician's explanation so let's go for the one for the first one it says myasthenia gravis is an autoimmune disease that targets the acetylcholine receptors on your muscle cells and produce movement? well, this is actually false, okay? because it is true that myasthenia gravis targets the acetylcholine receptors, but they are going to block them.

01:04 They are not going to allow the receptor to bind acetylcholine, okay? so this is not going to cause movement.

01:11 It is going to cause the opposite weakness.

01:16 Now, the next one says, is option three, that says, with reduced number of functional acetylcholine receptors available your muscles contract continuously leading to muscle weakness due to muscle fatigue and this one here is gonna be it's gonna be a false too okay so in this case um there is as there is no binding of acetylcholine with a receptor that is not going to be muscle contraction then you have statement four that says this muscle weakness is particularly noticeable noticeable in muscles that are used frequently such as those controlling breathing and swallowing and well this is true, ok this is true.

01:52 Then you have option 5 that says normally after acetylcholine causes a muscle contraction it is broken down by an enzyme called acetylcholinesterase and this one here is also true.

02:03 Ok this is also true, this enzyme is going to degrade acetylcholine after causing muscle contraction...

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