Q: Meselson & Stahl in 1958 used density gradient centrifugation to demonstrate DNA banding patterns that were consistent with the semi-conservative mode of replication of DNA. Describe thoroughly the consequences of conservative and dispersive DNA replication. What would organisms look like if a conservative or dispersive DNA replication were the model?
Added by Cristian H.
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In this model, the two daughter DNA molecules would be identical to each other but different from the original parental DNA molecule. If conservative DNA replication were the model, organisms would have a very limited ability to adapt to changing environments Show more…
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4. Explain how Meselson and Stahl proved that DNA replication was semi conservative, with reference to the diagram below? Explain the experiment? (3 marks) /3 Conservative Semi-conservative Dispersive CsCl ultracentrifugation
Adi S.
The Meselson-Stahl experiment (see Fig. $25-2$ ) proved that DNA undergoes semi-conservative replication in $E$. coli. In the "dispersive" model of DNA replication, the parent DNA strands are cleaved into pieces of random size, then joined with pieces of newly replicated DNA to yield daughter duplexes. Explain how the results of Meselson and Stahl's experiment ruled out such a model.
Meselson and Stahl used radioactive DNA labeling to demonstrate that DNA replication is semiconservative. However, what if their result was different and they saw the following: Parental 1st generation 2nd generation (light) DNA_ DNA= How would you interpret these results? Evidence of replication being dispersive, meaning that the parental and newly synthesized DNA are mixed together during replication. Based on this data, Conservative and Dispersive models are equally likely. Based on this data, Conservative, Semi-conservative, and Dispersive models are all equally likely. Evidence of replication being conservative, meaning that the parental DNA is left intact after replication. Evidence of replication being semiconservative, meaning that one strand is retained from parental DNA and the other strand is synthesized during replication.
Shaiju T.
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