Q1) A simple explanation of the action of an uncoupler of mitochondrial oxidative phosphorylation is that it is any agent that A. blocks the oxidation of reduced cytochrome c by cytochrome oxidase. B. prevents formation of ATP by interacting with and blocking proton transport through the proton translocating ATPase. C. acts to conduct protons back into the mitochondrial matrix without accompanying formation of ATP. D. blocks proton conductance and slows oxygen uptake rates. Q2) Uncouplers of oxidative phosphorylation A. increase ATP synthesis. B. decrease oxygen consumption. C. decrease substrate oxidation. D. short circuit a proton gradient. E. include substances such as penicillin.
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They do this by allowing protons to flow back into the mitochondrial matrix without passing through the ATP synthase, thus bypassing the production of ATP. The correct answer is: C. acts to conduct protons back into the mitochondrial matrix without accompanying Show more…
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1. Electrons from NADH are donated to the electron transport chain to produce the proton gradient that drives ATP synthase in a process called oxidative phosphorylation. Describe the components of the electron transport chain and how this creates a proton gradient and ATP synthesis. 2. NADH donates electrons to the ________ of the mitochondrial electron-transport chain. a) NADH dehydrogenase b) ubiquinone c) cytochrome c reductase d) cytochrome c oxidase
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