Q1) The oxygen saturation curve is shown below. The normal alveolar PO2 is 100 mmHg. The normal cell PO2 is 40 mmHg, but it drops to 20 mmHg with exercise. (1) What conclusion do you draw about the oxygen requirement during normal activity and during exercise? (2) What happen to oxygen release when the exercising cell warms up? (3) How does pH and PCO2 affect the oxygen saturation curve? Percent O2 saturation of hemoglobin 100 90 80 70 60 50 40 30 20 10 20 40 60 80 100 PO2 (mm Hg) Q2) (1) How is oxygen transported in the lung and in the tissues? (2) The red blood cells have a hemoglobin (MW 68000 g/mol) concentration of 150 g/L at a hematocrit of 0.45. Determine the total concentration of oxygen at an arterial PO2 of 100 mmHg.
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However, during exercise, the cell Po2 drops to 20 mmHg, indicating an increased oxygen requirement during exercise. Show more…
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According to the hemoglobin saturation curve below, how much oxygen do Patients 1, 2, and 3 deliver if the amount of oxygen in blood LEAVING the lungs is 85 mm Hg and the amount of oxygen in the blood RETURNING TO the lungs is 45 mm Hg? Patient 1: Blue (Dotted) Patient 2: Green (Solid) Patient 3: Pink (Dashed) 100 80 Hemoglobin Saturation 60 40 20 20 40 60 PO2 (mm Hg) 80 100 120 Patient 1: 20 Patient 2: 70 Patient 3: 92 Patient 1: 50 Patient 2: 65 Patient 3: 60 Patient 1: 8 Patient 2: 25 Patient 3: 70 O2 Patient 1: 15 Patient 2: 25 Patient 3: 38
Adi S.
Hemoglobin (abbreviated Hb) is a protein that is responsible for the transport of oxygen in the blood of mammals. Each hemoglobin molecule contains four iron atoms that are the binding sites for $\mathrm{O}_{2}$ molecules. The oxygen binding is $\mathrm{pH}$ dependent. The relevant equilibrium reaction is $$\mathrm{HbH}_{4}^{4+}(a q)+4 \mathrm{O}_{2}(g) \rightleftharpoons \mathrm{Hb}\left(\mathrm{O}_{2}\right)_{4}(a q)+4 \mathrm{H}^{+}(a q)$$ Use Le Châtelier's principle to answer the following. a. What form of hemoglobin, $\mathrm{HbH}_{4}^{4+}$ or $\mathrm{Hb}\left(\mathrm{O}_{2}\right)_{4},$ is favored in the lungs? What form is favored in the cells? b. When a person hyperventilates, the concentration of $\mathrm{CO}_{2}$ in the blood is decreased. How does this affect the oxygenbinding equilibrium? How does breathing into a paper bag help to counteract this effect? (See Exercise 146.) c. When a person has suffered a cardiac arrest, injection of a sodium bicarbonate solution is given. Why is this necessary? (Hint: $\mathrm{CO}_{2}$ blood levels increase during cardiac arrest.
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