Q7. Von Gierke disease is classified as type 1 and Type II. Type 1 is mainly due to a deficiency of G-6-phosphatase (your case). What is the molecular cause of Von Gierke disease type 1? The image to the right will help you.
Q8. Based on this figure, the deficiency of G-6-phosphatase results in the accumulation of G-6-P. Explain how this intermediate causes hypoglycemia, lactatemia, hyperuricemia (high uric acid in the blood), and hyperlipidemia (major clinical symptoms in this case).