Question 10 (1 point) ? Saved Which of the following...

Question 10 (1 point) ? Saved Which of the following mutations in DNA can result in a non-functioning protein? A mutation in a promoter region. A mutation in the coding exon. A mutation in an intron. All of the above.

Transcript

00:01 Hello, so let's answer now the question.

00:03 So let's start with question number nine.

00:07 So we are asked in this question, which of the following is least severe in the effect, in terms of the effect of the mutation into the phenotype of the organism? so least severe.

00:29 So the expansion of trinucleotide repeat and even the deletion, or based deletions results in a shame frame shift, sorry, frame shift, rather frame shift mutation that alters the reading frame of codons.

00:50 So basically, it is really severe.

00:53 Okay, so it will alter the reading of the entire amino acid sequence because of the expansion of the trinucleotide repeat and the deletion of basis and also the nonsense substitution or the nonsense mutation is caused by stop codon or the stop codon is inserted which will not permit the protein to develop or for protein to finish being translated so therefore the nonsense substitution is also a severe form of mutation that's why for this question, our answer here is we have the miscence, okay, the miscence substitution or the miscence mutation.

01:58 Okay, so the missing substitution or the missing mutation does not insert a stop codon, hence the entire protein sequence or the amino acid sequence will be translated, but there is only one problem.

02:15 And the one problem is there is one, amino acid that will be changed.

02:19 Though it is a mutation, but it is less severe than the other mutations in the options because, for example, again, the deletion and the expansion of trinuclated repeats, it will alter the entire sequence.

02:34 It is very severe.

02:37 And again, the nonsense is also severe...

Question

Question 10 (1 point) ? Saved Which of the following mutations in DNA can result in a non-functioning protein? A mutation in a promoter region. A mutation in the coding exon. A mutation in an intron. All of the above.

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