Question 10 of 17 © Macmillan Learning Classify the events as possible precursors for a professional antigen presenting cell (pAPC) activating Signal 1, Signal 2, or Signal 3 in an interaction with a naive CD4+ T cell. Not all of the events will be used. Signal 1 Signal 2 Signal 3 Answer Bank PRR signaling in pAPC activates CD80 expression PRR signaling in pAPC activates IL-2 expression IL-2R alpha chain gene expression Search
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The question asks to classify events as precursors for Signal 1, Signal 2, or Signal 3 in the context of a professional antigen-presenting cell (pAPC) activating a naive CD4+ T cell. We need to identify which events from the "Answer Bank" lead to which signal. Show more…
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Classify the events as possible precursors for a professional antigen presenting cell (pAPC) activating Signal 1, Signal 2, or Signal 3 in an interaction with a naïve CD4+ T cell. Not all of the events will be used. Signal 1 Signal 2 Signal 3 Answer Bank V(D)J recombination PRR signaling in pAPC activates IL-2 expression exogenous pathway of antigen presentation PRR signaling in pAPC activates CD80 expression IL-2α chain gene expression endogenous pathway of antigen presentation lineage commitment MHC restriction
Mauya M.
APCs deliver three kinds of signals to naïve T cells: 1) Activation, 2) Survival, and 3) Differentiation. Which one(s) is/are associated with proliferation? TCR binding to MHC-peptide Cytokines from the APC binding to cytokine receptors on the T cell Induction of somatic mutations of TCR genes CD28 on T cells binding to B7 on the APC CD28 on T cells binding to CTLA on the APC Selectin binding
Suman K.
Which of the following best describes the nature of signal 2 for the activation of naïve T cells? The TCR and coreceptor (CD4 or CD8) binding to MHC and peptide on the surface of an APC. The danger signal (called costimulation); This consists of CD28 on a T cell being bound by its ligand (B7-1/B7-2) on an APC. The production of IL-2 and the high affinity IL-2 receptor. The binding of CTLA-4 to its ligand (B7-1/B7-2) on an APC. What do naïve T cells do when they recognize antigen in the context of self MHC, but there is no costimulation? These T cells are stimulated to produce IL-2 and high affinity IL-2 receptor. This leads to autocrine and paracrine stimulation of the cells to proliferate and differentiate into effector and memory T cells. These T cells immediately undergo apoptosis. These T cells will not be activated and may become unresponsive (tolerant) to subsequent exposure to antigen. These T cells will migrate to the thymus to continue the maturation process.
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